Princess Nicotine; or, The Smoke Fairy (1909, dir.J. Stuart Blackton) (via brightlightsfilm.com)
This 5-minute silent film is less notable for its relatively simple plot (a smoker is woken up by two mischievous fairies who proceed to torment him) than for its groundbreaking visual effects (many of the shots are designed to show the tiny fairies interacting with objects much larger than themselves). When Princess Nicotine; or, The Smoke Fairy was released a century ago, the special effects were considered so advanced & state-of-the-art that scientific journals published articles about them.
The film is viewable on youtube here.